Skeletal reconstruction by vascularized allogenic bone transplantation: effects of statin in rats
Skeletal reconstruction by vascularized allogenic bone transplantation: effects of statin in rats
复制标题
血管化同种异体骨移植的骨骼重建：他汀类药物对大鼠的影响
DOI：
10.1097/01.tp.0000074992.49236.58
复制
发表时间：
2003
期刊：
影响因子：
6.2
通讯作者：
S. Kawai
中科院分区：
文献类型：
--
作者：
T. Ohno;M. Shigetomi;K. Ihara;T. Matsunaga;T. Hashimoto;H. Kawano;T. Sugiyama;S. Kawai
背景。据报道，一些他汀类药物可以抑制免疫系统并增加骨形态发生蛋白 2 基因的表达，骨形态发生蛋白 2 基因在骨再生中起着关键作用。方法。在大鼠胫骨-腓骨移植模型中研究了西立伐他汀对带血管同种异体骨移植骨骼重建的影响。移植后，用载体、低剂量西立伐他汀、高剂量西立伐他汀或环孢素A治疗受体大鼠。 结果。用低剂量西立伐他汀和载体处理的移植骨未能与受体骨结合。相比之下，高剂量西立伐他汀与环孢素A一样有效地诱导骨愈合。从组织学上看，高剂量西立伐他汀处理的移植骨是无生命的，但新骨形成发生在无生命皮质的外层。结论。这些结果表明他汀类药物可以促进骨折愈合。由于移植受者发生骨质疏松性骨折和高胆固醇血症的风险增加，因此他汀类药物可能是治疗这些患者的不错选择。
Background. Some statins have been reported to suppress the immune system and increase the expression of bone morphogenetic protein-2 gene that plays a pivotal role in bone regeneration. Methods. The effects of cerivastatin on skeletal reconstruction by vascularized bone allograft were investigated in a rat tibia-fibula graft model. After transplantation, the recipient rats were treated with vehicle, low-dose cerivastatin, high-dose cerivastatin, or cyclosporine A. Results. Transplanted bones treated with low-dose cerivastatin and vehicle failed to unite with the recipient bones. In contrast, high-dose cerivastatin induced the bone union as effectively as cyclosporine A. Histologically, high-dose cerivastatin-treated transplanted bones were nonvital, but new bone formation occurred at the outer layer of the nonvital cortex. Conclusion. These results indicate that statins could promote fracture healing. Because transplant recipients have the increased risks of osteoporotic fracture and hypercholesterolemia, statins may be a good choice in the treatment of these patients.