Challenges in comparing the safety of different vaccination schedules
Challenges in comparing the safety of different vaccination schedules
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DOI：
10.1016/j.vaccine.2013.02.054
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发表时间：
2013-04-19
期刊：
影响因子：
5.5
通讯作者：
Jackson, Michael L.
中科院分区：
文献类型：
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作者：
Jackson, Michael L.
随着美国对疫苗的犹豫增加，许多作者开始提出免疫实践咨询委员会推荐的儿童免疫计划的替代方案。由于家长可能相信这些作者提出的安全性主张，因此需要对替代疫苗接种计划的安全性进行评估。然而，比较不同疫苗接种计划的安全性存在许多方法学挑战。这些挑战包括定义疫苗接种史、定义安全性、适当建模疫苗之间的相互作用以及适当处理年龄影响。未能正确应对这些挑战可能会导致有偏差的结果。 (C) 2013 Elsevier Ltd. 保留所有权利。
As vaccine hesitancy has increased in the United States, various authors have begun proposing alternatives to the Advisory Committee on Immunization Practices' recommended childhood immunization schedule. Because parents may believe the safety claims made by such authors, evaluations of the safety of alternative vaccination schedules are needed. However, comparing the safety of different vaccination schedules has numerous methodologic challenges. These challenges include defining vaccination history, defining safety, appropriately modeling interactions between vaccines, and appropriately handling age effects. Failure to properly address these challenges can result in biased results. (C) 2013 Elsevier Ltd. All rights reserved.