Impaired Mitochondrial Mobility in Charcot-Marie-Tooth Disease.
Impaired Mitochondrial Mobility in Charcot-Marie-Tooth Disease.
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DOI：
10.3389/fcell.2021.624823
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发表时间：
2021
影响因子：
5.5
通讯作者：
Manor U
中科院分区：
文献类型：
--
作者：
Schiavon CR;Shadel GS;Manor U
Charcot-Marie-Tooth (CMT) disease is a progressive, peripheral neuropathy and the most commonly inherited neurological disorder. Clinical manifestations of CMT mutations are typically limited to peripheral neurons, the longest cells in the body. Currently, mutations in at least 80 different genes are associated with CMT and new mutations are regularly being discovered. A large portion of the proteins mutated in axonal CMT have documented roles in mitochondrial mobility, suggesting that organelle trafficking defects may be a common underlying disease mechanism. This review will focus on the potential role of altered mitochondrial mobility in the pathogenesis of axonal CMT, highlighting the conceptional challenges and potential experimental and therapeutic opportunities presented by this “impaired mobility” model of the disease.
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