Alcohol consumption and the risk of type 2 diabetes mellitus - Atherosclerosis risk in communities study
Alcohol consumption and the risk of type 2 diabetes mellitus - Atherosclerosis risk in communities study
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DOI：
10.1093/aje/154.8.748
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发表时间：
2001-10-15
影响因子：
5
通讯作者：
Brancati, FL
中科院分区：
文献类型：
--
作者：
Kao, WHL;Puddey, IB;Brancati, FL
关于饮酒和2型糖尿病风险之间的联系的证据仍然不一致，特别是关于男性和女性的差异。作者对社区动脉粥样硬化风险研究(1990-1998)的12261名中年参与者进行了一项与饮酒相关的2型糖尿病风险的前瞻性研究，并对他们进行了3至6年的跟踪调查。基线上的饮酒量包括终生戒酒者、曾经饮酒者和目前不同水平的饮酒者。糖尿病事件通过血糖测量和自我报告来确定。在调整了潜在的混杂因素后，发现每周饮酒21杯的男性与每周饮酒少于或等于1杯的男性相比，患糖尿病的风险增加(优势比=1.50，95%可信区间：1.02，2.20)，而女性没有发现明显的关联。在每周饮酒的男性中，糖尿病风险的增加主要与烈酒有关，而与啤酒或葡萄酒的消费无关。每周饮用14杯烈性酒的男性与目前饮酒但报告不经常使用烈性酒、啤酒或葡萄酒的男性相比，发生糖尿病的相对几率为1.82(95%可信区间：1.14，2.92)。这项研究的结果支持了这样的假设，即大量饮酒会增加中年男性患糖尿病的风险。然而，更适度的饮酒并不会增加中年男性和女性患2型糖尿病的风险。
Evidence regarding the association between alcohol consumption and type 2 diabetes risk remains inconsistent, particularly with regard to male-female differences. The authors conducted a prospective study of type 2 diabetes risk associated with alcohol consumption in a cohort of 12,261 middle-aged participants of the Atherosclerosis Risk in Communities Study (1990-1998), who were followed between 3 and 6 years. Alcohol consumption at baseline was characterized into lifetime abstainers, former drinkers, and current drinkers of various levels. Incident diabetes was determined by blood glucose measurements and self-report. After adjustment for potential confounders, an increased risk of diabetes was found in men who drank > 21 drinks/week when compared with men who drank less than or equal to1 drink/week (odds ratio = 1.50, 95% confidence interval: 1.02, 2.20) while no significant association was found in women. This increased diabetes risk among men who drank > 21 drinks/week was predominantly related to spirits rather than to beer or wine consumption. The relative odds of incident diabetes in a comparison of men who drank > 14 drinks of spirits per week with men who were current drinkers but reported no regular use of spirits, beer, or wine were 1.82 (95% confidence interval: 1.14, 2.92). Results of this study support the hypothesis that high alcohol intake increases diabetes risk among middle-aged men. However, more moderate levels of alcohol consumption do not increase risk of type 2 diabetes in either middle-aged men or women.