Stimulation of Wound Healing by Epidermal Growth Factor
Stimulation of Wound Healing by Epidermal Growth Factor
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表皮生长因子刺激伤口愈合
DOI：
10.1097/00000658-198604000-00007
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发表时间：
1986
影响因子：
9
通讯作者：
B. Gerdin
中科院分区：
文献类型：
--
作者：
J. Niinikoski;L. Lebel;B. Gerdin
本工作是为了研究不同剂量的局部应用表皮生长因子（EGF）对大鼠肉芽组织发育的影响。圆柱形中空海绵植入物被用作肉芽组织生长的诱导基质。在试验组中，植入物每天注射含有0.2、1或5 μg EGF的0.1%白蛋白溶液，而对照组的植入物仅用载体溶液进行相应处理。在植入后7天对海绵圆柱体中的肉芽组织进行分析。观察到EGF对肉芽组织形成的刺激性，剂量依赖性作用：细胞性增加，如核酸量升高所证明的，胶原蛋白和糖胺聚糖的积累增强。
This work was undertaken to study the effects of various doses of locally applied epidermal growth factor (EGF) on developing granulation tissue in rats. Cylindrical hollow sponge implants were used as an inductive matrix for the growth of granulation tissue. In the test groups, the implants were injected daily with a solution containing 0.2, 1, or 5 μg of EGF in 0.1% albumin while the implants of the control group were treated correspondingly with the carrier solution only. Analyses of granulation tissue in the sponge cylinders were carried out 7 days after implantation. A stimulatory, dose-dependent effect of EGF on granulation tissue formation was observed: cellularity increased, as evidenced by the elevated amounts of nucleic acids, and accumulation of collagen and glycosaminoglycans was enhanced.