Dehydroepiandrosterone-sulfate is associated with cardiovascular reactivity to stress in women
Dehydroepiandrosterone-sulfate is associated with cardiovascular reactivity to stress in women
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DOI：
10.1016/j.psyneuen.2016.04.005
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发表时间：
2016-07
影响因子：
3.7
通讯作者：
K. Hirokawa;T. Ohira;M. Nagayoshi;Mitsugu Kajiura;H. Imano;A. Kitamura;M. Kiyama;T. Okada;H. Iso
中科院分区：
文献类型：
--
作者：
K. Hirokawa;T. Ohira;M. Nagayoshi;Mitsugu Kajiura;H. Imano;A. Kitamura;M. Kiyama;T. Okada;H. Iso
心血管应激反应是动脉粥样硬化和心脏事件的预测因子。脱氢表雄酮（DHEA）可以预防心血管疾病，但以前的研究结果并不一致。我们调查了日本女性和男性的脱氢表雄酮硫酸盐（DHEA-s）和心血管应激反应之间的关系。在979名日本健康受试者（641名女性和338名男性）中，在休息和两种类型的任务下测量了血清DHEA-s水平、收缩压（SBP）和舒张压（DBP）、心率、心率变异性和外周血流量。在任务期间和任务后期间测量变量的平均差异计算为压力反应性的变化。针对多种潜在混杂因素调整应激反应性变量。在女性中，DHEA-s水平与SBP和DBP的变化呈正相关（标准化β = 0.12，p = 0.020;分别为0.17，0.002）。根据绝经状态和其他生活方式因素（例如，吸烟情况、饮酒情况）。绝经前仍存在显着的正相关性（标准化β = 0.13，p = 0.037; 0.18，0.005），不吸烟（0.12，0.010; 0.18，<0.001），非饮酒女性（0.14，0.021; 0.21，0.001），无病史女性（0.15，0.020; 0.20，0.001）。在男性中，DHEA-s水平与应激反应的变化之间没有显着关联。DHEA-s水平与女性高血压对压力的反应呈正相关，绝经、吸烟和饮酒改变了这种关联。
Cardiovascular stress reactivity is a predictor of atherosclerosis and cardiac events. Dehydroepiandrosterone (DHEA) protects against cardiovascular diseases, but results among previous studies have been inconsistent. We investigated the association between dehydroepiandrosterone-sulfate (DHEA-s) and cardiovascular stress reactivity in Japanese women and men. Among 979 healthy Japanese subjects (641 women and 338 men), serum levels of DHEA-s, systolic blood pressure (SBP) and diastolic blood pressure (DBP), heart rate, heart rate variability, and peripheral blood flow were measured under rest and two types of task. Mean differences in measured variables during tasks and a post-task period were calculated as changes in stress reactivity. Variables of stress reactivity were adjusted for multiple potential confounding factors. In women, DHEA-s levels showed positive associations with changes in SBP and DBP (standardized beta = 0.12, p = 0.020; 0.17, 0.002, respectively). Stratification by menopausal status and other lifestyle factors (e.g., smoking status, alcohol consumption) were conducted. Significant positive associations remained in pre-menopausal (standardized beta = 0.13, p = 0.037; 0.18, 0.005), non-smoking (0.12, 0.010; 0.18, <0.001), and non-drinking women (0.14, 0.021; 0.21, 0.001), and women without a medical history (0.15, 0.020; 0.20, 0.001). In men, there was no significant association between DHEA-s levels and changes in stress reactivity. DHEA-s levels were positively associated with high blood-pressure reactivity to stress in women, and being menopausal, smoking, and alcohol consumption modified this association.