REDUCED RESPONSE TO HEPATITIS-B VIRUS VACCINATION IN BOYS WITH STEROID-SENSITIVE NEPHROTIC SYNDROME
REDUCED RESPONSE TO HEPATITIS-B VIRUS VACCINATION IN BOYS WITH STEROID-SENSITIVE NEPHROTIC SYNDROME
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DOI：
10.1007/bf00878360
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发表时间：
1992-05-01
影响因子：
3
通讯作者：
DELGADO, R
中科院分区：
文献类型：
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作者：
LAMANNA, A;POLITO, C;DELGADO, R
对18名激素敏感性肾病综合征（SSNS）男孩（年龄5.7 ± 2.4岁）和21名健康男孩（年龄5.6 ± 3.8岁）进行了抗B型肝炎病毒（HBV）的疫苗接种。在开始接种疫苗后1、6、8、12、18和24个月，对疫苗接种有反应的患者百分比显著低于对照组。在6个月和24个月时，应答者产生的HBV表面抗原抗体滴度在患者中显著低于对照组。患有SSNS的男孩对HBV疫苗接种的反应受损。
Vaccination against hepatitis B virus (HBV) was performed in 18 boys (aged 5.7 +/- 2.4 years) suffering from steroid-sensitive nephrotic syndrome (SSNS) and in a control group of 21 healthy boys (aged 5.6 +/- 3.8 years). The percentage of patients who responded to vaccination was significantly lower than the control group 1, 6, 8, 12, 18 and 24 months after the start of vaccination. The titre of antibodies to HBV surface antigen produced by responders at 6 and 24 months was significantly lower in patients than in the control group. Boys with SSNS have an impaired response to HBV vaccination.