Imaging how attention modulates pain in humans using functional MRI
Imaging how attention modulates pain in humans using functional MRI
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DOI：
10.1093/brain/awf022
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发表时间：
2002-02-01
期刊：
影响因子：
14.5
通讯作者：
Tracey, I
中科院分区：
文献类型：
--
作者：
Bantick, SJ;Wise, RG;Tracey, I
目前的临床和实验文献强烈支持这种现象，即当注意力从有害刺激上分散时，疼痛感知会减少。本研究使用功能性MRI来阐明潜在的神经系统和相关机制。Stroop任务的类似物，计数Stroop，被用作认知分心任务，同时受试者接受间歇性疼痛热刺激。当受试者参加认知要求较高的干扰任务时，疼痛强度得分明显低于要求较低的中性任务。当受试者在疼痛刺激中分心时，与前扣带皮层（ACC）和眶额区相关的大脑区域显示出增加的激活。相比之下，疼痛基质的许多区域（即丘脑、脑岛、ACC的认知区）显示出激活减少，支持疼痛感知减少的行为结果。
Current clinical and experimental literature strongly supports the phenomenon of reduced pain perception whilst attention is distracted away from noxious stimuli. This study used functional MRI to elucidate the underlying neural systems and mechanisms involved. An analogue of the Stroop task, the counting Stroop, was used as a cognitive distraction task whilst subjects received intermittent painful thermal stimuli. Pain intensity scores were significantly reduced when subjects took part in the more cognitively demanding interference task of the counting Stroop than in the less demanding neutral task. When subjects were distracted during painful stimulation, brain areas associated with the affective division of the anterior cingulate cortex (ACC) and orbitofrontal regions showed increased activation. In contrast, many areas of the pain matrix (i.e. thalamus, insula, cognitive division of the ACC) displayed reduced activation, supporting the behavioural results of reduced pain perception.