Nuclear tyrosine kinases: From Abl to WEE1
Nuclear tyrosine kinases: From Abl to WEE1
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DOI：
10.1016/s0955-0674(96)80063-9
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发表时间：
1996-04-01
影响因子：
7.5
通讯作者：
Pendergast, AM
中科院分区：
文献类型：
--
作者：
Pendergast, AM
最近的发现将这些蛋白质与细胞周期的组成部分和转录机制联系起来，支持了蛋白质酪氨酸激酶在细胞核中发挥关键作用的观点。其中一些酪氨酸激酶定位于细胞的核和细胞质区室，并且可以协调细胞质中的信号转导事件与细胞核中的特定变化。这些蛋白质包括 Abl、Rak、Fes 和 Fer。过去的一年在阐明导致 Abl 酪氨酸激酶激活的途径和识别新的 Abl 靶点方面取得了重大进展。最近在了解细胞核特异性人 WEE1 酪氨酸激酶的调节方面也取得了进展。核酪氨酸激酶可能参与多种细胞过程的调节，包括转录、DNA 修复和细胞周期。
The notion of a critical role for protein tyrosine kinases in the nucleus is supported by recent findings linking these proteins with components of the cell cycle and with the transcription machinery. Several of these tyrosine kinases localize to both nuclear and cytoplasmic compartments of the cell, and may coordinate signal transduction events in the cytoplasm with specific changes in the nucleus. Among these proteins are Abl, Rak, Fes and Fer, The past year has brought significant progress both towards the elucidation of the pathways that lead to activation of the Abl tyrosine kinase and towards the identification of novel Abl targets. Recent advances have also been made in understanding the regulation of the nucleus-specific human WEE1 tyrosine kinase. Nuclear tyrosine kinases may participate in the regulation of multiple cellular processes including transcription, DNA repair and the cell cycle.