Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI
Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI
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DOI：
10.1118/1.1869612
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发表时间：
2005-04-01
期刊：
影响因子：
3.8
通讯作者：
Yodh, AG
中科院分区：
文献类型：
--
作者：
Choe, R;Corlu, A;Yodh, AG
我们采用弥散光学断层扫描 (DOT) 来追踪新辅助化疗期间患有局部晚期浸润性乳腺癌的女性受试者的治疗进展。总血红蛋白浓度和散射的三维图像识别出肿瘤。我们的测量显示化疗过程中肿瘤缩小，与同一受试者的磁共振图像相当一致。随着时间的推移，还观察到肿瘤和正常组织之间的总血红蛋白浓度对比降低。结果证明了 DOT 在测量化疗期间乳腺病变生理参数方面的潜力。 (c) 2005 年美国医学物理学家协会。
We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy. (c) 2005 American Association of Physicists in Medicine.