Social Interactions, Stress, and Immunity
Social Interactions, Stress, and Immunity
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DOI：
10.1016/j.iac.2009.02.006
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发表时间：
2009-05-01
影响因子：
2.6
通讯作者：
Sheridan, John F.
中科院分区：
文献类型：
--
作者：
Avitsur, Ronit;Powell, Nicole;Sheridan, John F.
本文综述了以反复失败为特征的社会应激实验模型所引起的内分泌和免疫变化。数据表明，面对社会压力源的小鼠可能会根据环境条件和先前的经验产生不同的行为应对反应。虽然慢性压力源；通常会抑制免疫功能，增加宿主对疾病的易感性，但并非所有情况都是如此。例如，在个体面临反复受伤机会的条件下，维持甚至增强免疫反应可能是一种适应性优势。社会破坏后糖皮质激素耐药性的发展可能就是这样一种机制，允许动物在抗炎应激激素存在的情况下愈合损伤和清除入侵微生物。
This article summarizes the endocrine and immune changes induced by an experimental model for social stress characterized by repeated defeat. Data indicate that mice facing a social stressor may use different behavioral coping responses based on the environmental conditions and previous experiences. Although chronic stressors; generally suppress immune function and increase a host's susceptibility to disease, this may not be always true in all cases. For example, under conditions in which individuals face the chance of being injured repeatedly, it may be an adaptive advantage to maintain or even enhance an immune response. The development of glucocorticoid resistance after social disruption may be such a mechanism, allowing animals to heal injuries and clear invading microbes in the presence of the anti-inflammatory stress hormones.