SH2/SH3 SIGNALING PROTEINS
SH2/SH3 SIGNALING PROTEINS
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DOI：
10.1016/0959-437x(94)90087-6
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发表时间：
1994-02-01
影响因子：
4
通讯作者：
SCHLESSINGER, J
中科院分区：
文献类型：
--
作者：
SCHLESSINGER, J
SH2 和 SH3 结构域是小蛋白质模块，可介导由蛋白酪氨酸激酶激活的信号转导途径中的蛋白质-蛋白质相互作用。 SH2 结构域与生长因子受体和其他磷蛋白中含有短磷酸酪氨酸的序列结合。 SH3 结构域通过含有脯氨酸和疏水性氨基酸的序列与靶蛋白结合。含有 SH2 和 SH3 结构域的蛋白质，例如 Grb2 和磷脂酶 C gamma，利用这些模块将受体和细胞质蛋白酪氨酸激酶分别连接到 Ras 信号通路和磷脂酰肌醇水解。几个SH2和SH3结构域的三维结构已通过NMR和X射线晶体学确定，并且它们特异性的分子基础已开始被揭示。
SH2 and SH3 domains are small protein modules that mediate protein-protein interactions in signal transduction pathways that are activated by protein tyrosine kinases. SH2 domains bind to short phosphotyrosine-containing sequences in growth factor receptors and other phosphoproteins. SH3 domains bind to target proteins through sequences containing proline and hydrophobic amino acids. SH2 and SH3 domain containing proteins, such as Grb2 and phospholipase C gamma, utilize these modules in order to link receptor and cytoplasmic protein tyrosine kinases to the Ras signaling pathway and to phosphatidylinositol hydrolysis, respectively. The three-dimensional structures of several SH2 and SH3 domains have been determined by NMR and X-ray crystallography, and the molecular basis of their specificity is beginning to be unveiled.