Microglial transplantation increases amyloid-β clearance in Alzheimer model rats
Microglial transplantation increases amyloid-β clearance in Alzheimer model rats
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DOI：
10.1016/j.febslet.2007.01.009
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发表时间：
2007-02-06
期刊：
影响因子：
3.5
通讯作者：
Tooyama, Ikuo
中科院分区：
文献类型：
--
作者：
Takata, Kazuyuki;Kitamura, Yoshihisa;Tooyama, Ikuo
淀粉样蛋白- β (A β)肽免疫是治疗阿尔茨海默病（AD）的一种方法，它可以减少大脑A β和小胶质细胞A β的吞噬，这是一种降低AD的机制。我们在海马内注射A β后将大鼠小胶质细胞移植到大鼠侧脑室，然后研究外源性小胶质细胞对A β清除的贡献。通过磁共振成像和组织化学分析检测外源性小胶质细胞从侧脑室向A β斑块的迁移，移植增加了A β的清除率。这些结果表明外源性小胶质细胞可能对阿尔茨海默病的治疗方法有用。(c) 2007年欧洲生化学会联合会。Elsevier B.V.版权所有。
Immunization with amyloid-beta (A beta) peptides, a therapeutic approach in Alzheimer's disease (AD), reduces brain A beta, and microglial A beta phagocytosis has been proposed as an AD-lowering mechanism. We transplanted rat microglia into the rat lateral ventricle just after intra-hippocampal A beta injection, and then investigated the contribution of exogenous microglia to A beta clearance. Migration of exogenous microglia from the lateral ventricle to A beta plaque was detected by magnetic resonance imaging and histochemical analysis, and the clearance of A beta was increased by transplantation. These results suggest the possible usefulness of exogenous microglia to the therapeutic approach in AD. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.