Recent advances in understanding phosphoinositide signaling in the nervous system.
Recent advances in understanding phosphoinositide signaling in the nervous system.
复制标题
DOI：
10.12688/f1000research.16679.1
复制
发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Dickson, Eamonn James
中科院分区：
文献类型：
--
作者：
Dickson, Eamonn James
多聚磷酸肌醇（PPIn）是哺乳动物细胞中重要的信号传导磷脂，对所有细胞膜的特性和信号级联都有重要贡献。它们通过在膜-细胞质界面与细胞蛋白质的选择性相互作用对膜稳态施加调节控制。这篇综述文章简要总结了我们目前对PPIn在哺乳动物神经元中协调和调节关键的电和化学信号事件以及其代谢改变后出现的重要神经病理生理条件的关键作用的理解。
Polyphosphoinositides (PPIn) are essential signaling phospholipids that make remarkable contributions to the identity of all cellular membranes and signaling cascades in mammalian cells. They exert regulatory control over membrane homeostasis via selective interactions with cellular proteins at the membrane-cytoplasm interface. This review article briefly summarizes our current understanding of the key roles that PPIn play in orchestrating and regulating crucial electrical and chemical signaling events in mammalian neurons and the significant neuro-pathophysiological conditions that arise following alterations in their metabolism.