Biomechanical properties of vaginal tissue: preliminary results
Biomechanical properties of vaginal tissue: preliminary results
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DOI：
10.1007/s00192-007-0533-3
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发表时间：
2008-06-01
影响因子：
1.8
通讯作者：
Cosson, Michel
中科院分区：
文献类型：
--
作者：
Rubod, Chrystele;Boukerrou, Malik;Cosson, Michel
本研究的目的是表征阴道组织的生物力学特性，以开发盆腔器官脱垂 (POP) 的准确治疗方法。经伦理委员会同意，在五名患者（POP）脱垂治疗期间和五具未发现盆底功能障碍（非盆腔器官脱垂）的尸体上提取脱垂的阴道组织。进行单轴拉伸，并对结果进行分析。实验结果的个体重复性良好，结果突出了应力（每单位表面的力）和应变（l-l(0)/l(0)）之间的非线性关系以及破裂出现前的非常大的变形。这项实验研究首次证明阴道组织的机械行为必须被定义为具有大变形的超弹性。为了开发用于 POP 治疗和盆底数值模拟的精确合成假体，必须考虑到这种反应。
The aim of this study is to characterise the biomechanical properties of vaginal tissue to develop an accurate cure of pelvic organ prolapse (POP). Prolapsed vaginal tissues were extracted during the prolapse cure of five patients (POP) and on five cadavers without noticed pelvic floor dysfunction (non-pelvic organ prolapse) with agreement of the ethics committee. Uni-axial tension was performed, and the results were analysed. Individual reproducibility of experimental results was good, and the results highlight the non-linear relationship between stress (force per unit of surface) and strain (l-l(0)/l(0)) and very large deformation before rupture appearance. This experimental study has proven for the first time that the mechanical behaviour of vaginal tissue has to be defined as hyperelastic with a large deformation. This response has to be taken into account to develop accurate synthetic prostheses for POP cure and in the numerical simulation of the pelvic floor.