Circular RNAs Act as miRNA Sponges
Circular RNAs Act as miRNA Sponges
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DOI：
10.1007/978-981-13-1426-1_6
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发表时间：
2018-01-01
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影响因子：
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通讯作者：
Panda, Amaresh Chandra
中科院分区：
文献类型：
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作者：
Panda, Amaresh Chandra
动物细胞中表达的大部分RNA缺乏蛋白质编码能力。与其他细胞RNA不同，环状（circ）RNA包括一个大家族的非编码（nc）RNA，缺乏5'或3'末端。高通量RNA测序和新的生物信息学工具的改进已经导致在各种生物体中鉴定出数千种circRNA。CircRNA可以通过影响转录、mRNA周转以及通过海绵状RNA结合蛋白和microRNA的翻译来调节基因表达。鉴于circRNA对miRNA活性的广泛影响，人们对理解circRNA对基因调控的miRNA海绵作用的影响有着巨大的兴趣。本文就miRNA-circRNA相互作用及其影响基因表达的机制作一综述。
Majority of RNAs expressed in animal cells lack protein-coding ability. Unlike other cellular RNAs, circular (circ) RNAs include a large family of noncoding (nc)RNAs that lack the 5' or 3' ends. The improvements in high-throughput RNA sequencing and novel bioinformatics tools have led to the identification of thousands of circRNAs in various organisms. CircRNAs can regulate gene expression by influencing the transcription, the mRNA turnover, and translation by sponging RNA-binding proteins and microRNAs. Given the broad impact of circRNA on miRNA activity, there is huge interest in understanding the impact of miRNA sponging by circRNA on gene regulation. In this review, we summarize our current knowledge of the miRNA-circRNA interaction and mechanisms that influence gene expression.