Guillain-Barré syndrome in mother and newborn child
Guillain-Barré syndrome in mother and newborn child
复制标题
母亲和新生儿的吉兰-巴利综合征
DOI：
10.1016/s0140-6736(97)24001-8
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
J. Tmost
中科院分区：
文献类型：
--
作者：
G. Luijckx;J. Vles;M. Baets;B. Buchwald;J. Tmost
一位33岁的女性在怀孕29周时因进行性对称上升性四肢无力和呼吸窘迫入院。guillain - barr<s:1>综合征（GBS）是根据临床症状、脑脊液检查和电生理检查诊断的。大剂量静脉注射免疫球蛋白（每天0.4 g / kg体重，连用5天）未导致临床改善，开始血浆置换。4个月后病情逐渐好转。有近期巨细胞病毒（CMV）感染的血清学证据。血清IgM神经节苷脂GM1抗体呈强阳性，IgG神经节苷脂GM1、GM2和GQ1b抗体呈阴性。通过记录量子终板电流，研究血浆滤液对小鼠神经肌肉传递的影响。
A 33-year-old woman was admitted to hospital in the 29th week of pregnancy because of progressive symmetric ascending weakness of her legs and arms and respiratory distress. Guillain-Barré syndrome (GBS) was diagnosed on the basis of clinical signs, cerebrospinal fluid examination, and electrophysiological studies. High-dose intravenous immunoglobulin (0· 4 g per kg of body weight per day for 5 days) did not lead to clinical improvement and plasma exchange was started. Her condition gradually improved over 4 months. There was serological evidence of recent cytomegalovirus (CMV) infection. Serum IgM ganglioside GM1 antibodies were strongly positive, whereas IgG ganglioside GM1, GM2, and GQ1b antibodies were negative. The plasma filtrate's effect on neuromuscular transmission was investigated in mice by recording quantal endplate currents.