Maternal and perinatal characteristics in relation to neuroblastoma
Maternal and perinatal characteristics in relation to neuroblastoma
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DOI：
10.1002/cncr.22486
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发表时间：
2007-03-01
期刊：
影响因子：
6.2
通讯作者：
Mueller, Beth A.
中科院分区：
文献类型：
--
作者：
Chow, Eric J.;Friedman, Debra L.;Mueller, Beth A.
背景神经母细胞瘤是婴儿中最常见的恶性肿瘤，但其危险因素仍然知之甚少。由于大多数患者出现在生命的最初几年，因此假设产前和围产期暴露可能有助于神经母细胞瘤的发病机制。通过使用1980年至2004年华盛顿州的出生和癌症登记记录进行了一项基于人群的病例对照研究。本文比较了240例神经母细胞瘤和2400例对照组的出生和出院记录的母婴特征。神经母细胞瘤与主要先天性异常的存在相关（比值比[OR]，6.86; [95%CI]，2.92-16.08），特别是与心脏异常相关（OR，5.84; 95%CI，1.93-17.66），即使排除了原发肿瘤附近的异常。观察到与母亲妊娠期糖尿病的临界关联（OR，1.84; 95%CI，0.98-3.47）。当分析仅限于1岁以下被诊断的儿童时，这两种关联的程度更大。这项以人群为基础的研究结果支持了先前的病例对照研究，这些研究确定了神经母细胞瘤和先天性畸形之间的病因学联系。然而，据作者所知，神经母细胞瘤和母亲糖尿病之间的关系以前没有报道，需要进一步研究。
BACKGROUND. Neuroblastoma is the most common malignancy among infants, but risk factors remain poorly understood. Because most patients present in the first few years of life, it has been hypothesized that prenatal and perinatal exposures may contribute to the pathogenesis of neuroblastoma.METHODS. A population-based case-control study was conducted by using linked birth and cancer registry records from 1980 to 2004 in Washington State. Maternal and infant characteristics from birth and hospital discharge records for 240 cases of neuroblastoma and 2400 controls were compared.RESULTS. Neuroblastoma was associated with the presence of major congenital abnormalities (odds ratio [OR], 6.86; [95% CI], 2.92-16.08), particularly with cardiac abnormalities (OR, 5.84; 95% CI, 1.93-17.66), even after excluding abnormalities near the primary tumor. A borderline association was observed with maternal gestational diabetes (OR, 1.84; 95% CI, 0.98-3.47). The magnitude of both associations was greater when the analysis was limited to children who were diagnosed at age < 1 year.CONCLUSIONS. The findings from this population-based study supported prior case-control studies that identified an etiologic link between neuroblastoma and congenital abnormalities. However, to the authors' knowledge, the association between neuroblastoma and maternal diabetes has not been reported previously and requires further study.