Association Among Age-Related Tongue Muscle Abnormality, Tongue Pressure, and Presbyphagia: A 3D MRI Study
Association Among Age-Related Tongue Muscle Abnormality, Tongue Pressure, and Presbyphagia: A 3D MRI Study
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DOI：
10.1007/s00455-020-10165-4
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发表时间：
2020-08-02
期刊：
影响因子：
2.6
通讯作者：
Domen, Kazuhisa
中科院分区：
文献类型：
--
作者：
Nakao, Yuta;Yamashita, Taiji;Domen, Kazuhisa
肌肉老化，如骨质疏松症，会对运动活动产生不利影响。然而，很少有研究阐明舌的衰老生理机制与肌肉成分的变化相一致。本研究旨在观察舌质成分随年龄增长的变化，探讨舌脂量对舌压和吞咽功能的影响。包括20名没有头颈癌、中风或神经肌肉疾病的社区老年人和20名健康的年轻人。用三维磁共振成像(MRI)和Dixon MRI测量舌体积、舌脂肪质量、舌瘦肌质量和舌脂肪百分比。同时测量舌压。通过摄像透视评价老年人的吞咽功能，并用穿透吸入量表(PAS)和标准化残留率量表(NRRS)进行评价。随着年龄的增长，舌脂量和舌脂率显著增加。老年参与者的舌脂百分比为20%，是年轻参与者的两倍。舌体积和舌瘦肌质量差异无统计学意义。舌脂量与舌脂百分比、舌压呈显著负相关。反之，舌体积与舌压力之间没有显著的相关性。舌肌成分对PAS和NRRS无明显影响。随着年龄的增长，舌质中脂肪含量的增加是舌质成分的主要变化，这与低舌压有关。因此，不仅要注意舌量，更要注意舌肌的质量。
Muscle aging such as sarcopenia adversely affects motor activities. However, few studies have elucidated the aging physiological mechanism of tongue concerted with the changes muscle composition. The present study aimed to examine the tongue composition changes to detect the effect of tongue fat mass on tongue pressure and swallowing function with aging. Twenty community-dwelling elderly without head and neck cancer, stroke, or neuromuscular disease and 20 healthy young were included. Tongue volume, tongue fat mass, tongue lean muscle mass, and tongue fat percentage were evaluated with 3D magnetic resonance imaging (MRI) and Dixon MRI. Tongue pressure was also measured. Swallowing function among elderly individuals was assessed via videofluorography, which was evaluated using the penetration-aspiration scale (PAS) and normalized residue ratio scale (NRRS). Tongue fat mass and tongue fat percentage significantly increased with aging. The tongue fat percentage of elderly participants was 20%, which was two times greater than that of young participants. No significant difference was observed in tongue volume and tongue lean muscle mass. A significantly negative correlation was observed between tongue fat mass and tongue fat percentage as well as tongue pressure. Conversely, tongue volume was not significantly correlated with tongue pressure. Tongue muscle composition exhibited no effect in the PAS and NRRS. Increase of fat mass is a major change in tongue composition with aging, which is associated with low tongue pressure. Thus, attention must be paid not only to tongue quantity but also to the quality of tongue muscles.