Tissue reaction and surface morphology of absorbable sutures after in vivo exposure
Tissue reaction and surface morphology of absorbable sutures after in vivo exposure
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DOI：
10.1007/s10856-006-0185-8
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发表时间：
2006-10-01
影响因子：
3.7
通讯作者：
Reis, Silvia R. A.
中科院分区：
文献类型：
--
作者：
Andrade, Miguel G. S.;Weissman, Ruben;Reis, Silvia R. A.
组织对缝线材料的反应主要取决于其组成的聚合物如何与组织相互作用。很少有体内研究评价与组织相互作用导致的缝线材料改性。本文旨在研究大鼠皮下组织对辐照聚乳糖910、聚对二氧环己酮、聚卡普隆25和铬肠的反应及其与材料所经历的超微结构改变的相关性。分别于术后1、2、3、7、14天观察组织学变化。在这些时期，从组织中取出材料，并通过扫描电子显微镜对其表面进行分析。辐照后的polyglactin 910刺激多核巨细胞的形成，其细丝发生分裂和溶解。聚对二氧环己酮中可见少量炎性细胞和瘢痕纤维化，表面出现三角形裂纹。在聚卡普隆25周围，记录到一些单核细胞的扩散浸润和纤维化，并在其表面上观察到火山口的形成。铬肠诱导坏死和肉芽组织，并在研究期间的组织中进行溶解。在本研究中，观察到缝合材料诱导分化的组织反应和形态学表面变化，表明适应症应个体化。
Tissue reaction to suture materials depends mainly on how the polymer they are composed of interacts with the tissues. There are few in vivo studies evaluating the suture material modifications resulting from its interaction with tissues. This paper aimed to study rat subcutaneous tissue reaction to irradiated polyglactin 910, polydioxanone, poliglecaprone 25 and chromic gut and its correlation with the ultra-structural alterations the materials undergo. The histological alterations were studied on the 1st, 2nd, 3rd, 7th and 14th day after suture implantations. In these periods, the materials were removed from the tissues and their surfaces were analyzed by scanning electron microscopy. Irradiated polyglactin 910 stimulated the formation of multinucleated giant cells and its filaments underwent cleavage and dissolution. In potydioxanone, a few inflammatory cells and scar fibrosis was observed, and triangular cracks appeared on its surface. Around the poliglecaprone 25, a diffused infiltration of a few mononuclear cells and fibrosis was recorded and formation of craters was observed on its surface. Chromic gut induced necrosis and granulation tissue and underwent dissolution in the tissues during the studied periods. In this study, it was observed that suture materials induced differentiated tissue reactions and morphologic surface changes, suggesting that indications should be individualized.