Examination of the role of the pedunculopontine tegmental nucleus in radial maze tasks with or without a delay
Examination of the role of the pedunculopontine tegmental nucleus in radial maze tasks with or without a delay
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DOI：
10.1016/s0306-4522(02)00108-2
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发表时间：
2002-01-01
期刊：
影响因子：
3.3
通讯作者：
Winn, P
中科院分区：
文献类型：
--
作者：
Keating, GL;Winn, P
随机觅食和延迟空间赢移这两项径向迷宫任务已被用于研究大鼠中通过皮质纹状体环连接的结构的功能和相互关系。例如前边缘皮质、伏隔核、腹侧苍白球和内侧丘脑。随机觅食任务旨在调查动物利用空间信息指导在线觅食的能力。此外，延迟空间双赢任务要求动物在延迟期内在工作记忆中保存空间相关信息。脚桥被盖核接收来自腹侧纹状体系统的直接输出，因此可能期望与它们共享功能特性。在本实验中，我们检查了双侧脚桥被盖核兴奋性毒性损伤的大鼠在这两项任务中的表现。在获得测试中，在进行任何训练之前，对大鼠进行双侧损伤，而在保留测试中，在进行损伤之前，对预定的标准性能水平进行适当的训练。在这两项任务中，以及在获取（无损伤前训练）和保留（损伤前训练）测试中，桥脚损伤的大鼠在选择进入手臂时犯的错误明显多于对照大鼠。脚桥被盖核损伤的大鼠中不存在运动障碍 - 相反，在速度测量（做出第一个手臂选择的潜伏期和后续选择的平均时间）上，脚桥被盖核损伤的大鼠比对照大鼠稍快。我们认为脚桥被盖核与额纹状体系统具有相同的功能特性，并且它形成脑干定向纹状体流出流的一部分，这与前额纹状体系统不同。通过丘脑的皮质折返系统。 (C) 2002 国际广播组织。由爱思唯尔科学有限公司出版。保留所有权利。
Two radial maze tasks, random foraging and delayed spatial win-shift, have been used to investigate, in rats, the functions and inter-relationships of structures connected through the corticostriatal loops. such as the prelimbic cortex, nucleus accumbens, ventral pallidum and mediodorsal thalamus. The random foraging task is designed to investigate animals' ability to use spatial information to guide foraging on-line. The delayed spatial win-shift task requires, in addition, that animals hold spatially relevant information in working memory across a delay period. The pedunculopontine tegmental nucleus receives direct output from ventral striatal systems and might therefore be expected to share functional properties with them.In the present experiments we have examined the performance of rats bearing bilateral excitotoxic lesions of the pedunculopontine tegmental nucleus on both of these tasks. In acquisition tests rats were given bilateral lesions before any training took place, while in retention tests appropriate training to predetermined criterion levels of performance took place before lesions were made. In both tasks, and in both acquisition (no prelesion training) and retention (prelesion training) tests, rats with pedunculopontine lesions made significantly more errors in selecting arms to enter than did control rats. There was no motor impairment present in pedunculopontine tegmental nucleus-lesioned rats - oil the contrary, on measures of speed (latency to make first arm choice and the mean time for subsequent choices) pedunculopontine-lesioned rats were slightly faster than control rats.We suggest that the pedunculopontine tegmental nucleus shares functional properties with frontostriatal systems and that it forms part of a brainstem-directed stream of striatal outflow different to the cortical re-entrant system via the thalamus. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.