Precise control of the surface and internal morphology of porous particles prepared using a spontaneous emulsification method
Precise control of the surface and internal morphology of porous particles prepared using a spontaneous emulsification method
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精确控制自发乳化法制备的多孔颗粒的表面和内部形貌
DOI：
10.1021/acs.langmuir.0c03311
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发表时间：
2021
期刊：
影响因子：
3.9
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Nishimura;S.;Murakami;Y.
采用“一步机械乳化”技术，通过控制自乳化和机械乳化，成功制备了表面和内部形貌可控的多孔粒子。多孔颗粒中的形态变化不是由水包油包水（w/o/w）乳液的制备条件确定的，而是由有利于自发制备的油包水（w/o）乳液液滴作为致孔剂稳定的溶剂的比例确定的。所提出的控制多孔颗粒形态的方法可以应用于所有基于使用有机溶剂的乳液溶剂蒸发的颗粒制备系统。多孔颗粒的形态控制的方法，独立的聚合物的浓度或组成被认为是有价值的未来调查的空气动力学性能和药物释放行为的生物医学多孔颗粒具有复杂的形状。
Porous particles with controllable surface and internal morphologies were successfully prepared by a “one-step mechanical emulsification” technique via the control of spontaneous emulsification where self-emulsification is followed by mechanical emulsification. The morphological changes in the porous particles were determined not by the preparation conditions of the water-in-oil-in-water (w/o/w) emulsion but by the proportion of solvents that favors the stabilization of the spontaneously prepared water-in-oil (w/o) emulsion droplets acting as porogens. The proposed method for controlling the morphology of the porous particles could be applied to all particle-preparation systems based on emulsion–solvent evaporation using organic solvents. The methodology for the morphological control of porous particles independent of the concentration or composition of the polymer is considered valuable for future investigations into the aerodynamic performance and drug-release behavior of biomedical porous particles with complex shapes.