Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
复制标题
DOI：
10.1126/science.abb7314
复制
发表时间：
2020-05-29
期刊：
影响因子：
56.9
通讯作者：
Haagmans, Bart L.
中科院分区：
文献类型：
--
作者：
Rockx, Barry;Kuiken, Thijs;Haagmans, Bart L.
目前大流行的冠状病毒，严重急性呼吸综合征-冠状病毒2(SARS-CoV-2)，最近在患有急性呼吸综合征冠状病毒病2019年(新冠肺炎)的患者中被发现。为了将其致病机制与以前出现的冠状病毒进行比较，我们用SARS-CoV-2或中东呼吸综合征(MERS)冠状病毒接种食蟹猴，并将其病理和病毒学与SARS-CoV感染的历史报道进行了比较。在感染SARS-CoV-2的猕猴中，病毒在没有临床症状的情况下从鼻咽部排出，并在弥漫性肺泡损伤灶的I型和II型肺泡细胞以及鼻、支气管和细支气管粘膜的纤毛上皮细胞中检测到病毒。在SARS-CoV感染中，肺部病变通常较严重，而在MERS-CoV感染中，肺部病变较轻，病毒主要在II型肺细胞中检测到。这些数据表明，SARS-CoV-2会导致猕猴患上类似新冠肺炎的疾病，并为测试预防和治疗策略提供了一个新的模型。
The current pandemic coronavirus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (COVID-19). To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or Middle East respiratory syndrome (MERS)-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV infection, lung lesions were typically more severe, whereas they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies.