Survival and prognostic factors of invasive aspergillosis after allogeneic bone marrow transplantation
Survival and prognostic factors of invasive aspergillosis after allogeneic bone marrow transplantation
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DOI：
10.1086/515116
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发表时间：
1999-02-01
影响因子：
11.8
通讯作者：
Gluckman, E
中科院分区：
文献类型：
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作者：
Ribaud, P;Chastang, C;Gluckman, E
为了确定患有侵袭性曲霉病（IA）的骨髓移植受者的生存预后因素，我们回顾性地回顾了1994年1月至1994年10月期间在我们的骨髓移植科观察到的27例IA病例。1997年9月30日，6名患者仍然活着且无病。 IA 诊断后的中位生存期为 36 天。根据单变量分析，在与生存相关的八个变量中，通过向后逐步 Cox 回归模型选择 IA 诊断时的移植物抗宿主病 (GVHD) 状态 (P = .0008) 和 IA 诊断前一周累积泼尼松龙剂量 (CPD1w) (P < .0001)。建立了三阶段分类：CPD1w小于或等于7 mg/kg（8名患者中的3名死亡；60天生存率，88%），CPD1w>7 mg/kg且无GVHD（10名患者中的9名死亡；60天生存率，20%），CPD1w>7 mg/kg且活动性急性2级或以上或广泛慢性GVHD（9名患者中9名死亡；60天生存率，20%）。 30 天存活率，0) (P < .0001)。
To determine prognostic factors for survival in bone marrow transplant recipients with invasive aspergillosis (IA), we retrospectively reviewed 27 IA cases observed in our bone marrow transplantation unit between January 1994 and October 1994, On 30 September 1997, six patients were alive and disease-free. The median survival after IA diagnosis was 36 days. Of eight variables found to be related to survival according to the univariate analysis, graft-versus-host disease (GVHD) status at IA diagnosis (P = .0008) and the cumulative prednisolone dose taken during the week preceding IA diagnosis (CPD1w) (P < .0001) were selected by a backward stepwise Cox regression model. A three-stage classification was established: CPD1w of less than or equal to 7 mg/kg (3 of 8 patients died; 60-day survival rate, 88%), CPD1w of >7 mg/kg and no GVHD (9 of 10 patients died; 60-day survival rate, 20%), and CPD1w of >7 mg/kg and active acute grade 2 or more or extensive chronic GVHD (9 of 9 patients died; 30-day survival rate, 0) (P < .0001).