Role of HIV-1 Vpu protein for virus spread and pathogenesis
Role of HIV-1 Vpu protein for virus spread and pathogenesis
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DOI：
10.1016/j.micinf.2008.07.006
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发表时间：
2008-07-01
影响因子：
5.8
通讯作者：
Adachi, Akio
中科院分区：
文献类型：
--
作者：
Nomaguchi, Masako;Fujita, Mikako;Adachi, Akio
VPU是灵长类免疫缺陷病毒中HIV-1所特有的一种病毒辅助蛋白。并且具有两个主要功能：在内质网中降解CD 4分子和增强病毒体从细胞中释放。最近鉴定的一种新的宿主限制因子，tetherin，作为一个Vpu拮抗剂表明，Vpu有助于病毒传播，促进后代病毒粒子的生产。本文综述了VPU的两种不同功能，并总结了其在HIV-1生命周期中的病毒学作用。(C)2008年，Elsevier Masson SAS。All rights reserved.
VPU is in accessory viral protein almost unique to HIV-1 among primate immunodeficiency viruses. and has two major functions: degradation of (he CD4 molecule ill endoplasmic reticulum and enhancement of virion release from cells. Recent identification of a novel host restriction factor, tetherin, as a Vpu-antagonist suggests that Vpu contributes to Virus spread by facilitating progeny virion production. This review focuses On the two distinct functions Of VPU and summarizes current knowledge oil its virological role in the HIV-1 life cycle. (C) 2008 Elsevier Masson SAS. All rights reserved.