Mitochondria and chronic effects of cancer therapeutics: The clinical implications.
Mitochondria and chronic effects of cancer therapeutics: The clinical implications.
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癌症治疗剂的线粒体和慢性作用：临床意义。
DOI：
10.1007/s11239-020-02313-2
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发表时间：
2021-05
影响因子：
4
通讯作者：
Abe JI
中科院分区：
文献类型：
--
作者：
Dominic A;Hamilton D;Abe JI
化学辐射的主要作用机制之一是诱导细胞衰老，这在与年龄相关的病理学中发挥关键作用。衰老的概念是进化的，衰老相关的重编程/干性的新的理解已经出现。这一新概念强调衰老不仅是细胞周期停滞，而且描述了由化疗诱导的衰老细胞亚群可以重新进入细胞周期，快速增殖，并获得“干性”状态。癌症治疗剂，包括化学-放射通过损伤线粒体触发毒性作用，主要是通过上调mtROS产生，导致随后的mtDNA和端粒DNA损伤，引发DNA损伤反应（DDR）。.本综述的最终目的是强调衰老相关的干性的新概念，这是由癌症治疗及其对血管系统的不良影响引起的。.我们将描述化学辐射如何通过同时在线粒体中产生活性氧和促进细胞核中的DDR来发挥毒性作用。我们讨论了临床靶向聚（ADP-核糖）聚合酶的潜力，它可能会防止下游线粒体功能障碍，并赋予保护癌症幸存者。总的来说，我们强调认识到几种癌症治疗的心脏毒性作用的后果的重要性，因此开发个性化的治疗方法来筛选炎症和心脏测试，以提高患者的生存率。
One of the major mechanisms of action of chemo-radiation is to induce cellular senescence, which exerts crucial roles in age-related pathology. The concept of senescence is evolved, and the novel understanding of senescence-associated reprogramming/stemness has emerged. This new concept emphasizes senescence as not only cell cycle arrest but describes that subsets of senescent cells induced by chemotherapy can re-enter cell cycles, proliferate rapidly, and acquire “stemness” status. Cancer therapeutics, including chemo-radiation triggers toxicity effects through damaging mitochondria, primarily through the upregulation of mtROS production leading to subsequent mtDNA and telomeric DNA damage elicitng DNA damage responses (DDR). . The ultimate goal of this review is to highlight the new concept of senescence-associated stemnessthat is induced by cancer treatment and its adverse effects on the vascular system. . We will describe how chemo-radiation exerts toxicity effects by simultaneously producing reactive oxygen species in mitochondria and promoting DDR in the nucleus. We discuss the potential of clinical targeting poly (ADP-ribose) polymerase which might prevent downstream mitochondrial dysfunction and confer protection to cancer survivors. Overall we emphasize the importance of recognizing the consequences of cardio-toxic effects of several cancer treatments and therefore developing personalized therapeutic approaches to screen for inflammatory and cardiac testing for better patient survival.
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影响因子：
45.3
作者：
Ness, Kirsten K.;Krull, Kevin R.;Hudson, Melissa M.
通讯作者：
Hudson, Melissa M.
影响因子：
3.5
作者：
Ren, JG;Xia, HL;Dai, YR
通讯作者：
Dai, YR
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
4.8
作者：
Henle, ES;Han, ZX;Linn, S
通讯作者：
Linn, S
影响因子：
64.8
作者：
Garcia-Prat, Laura;Martinez-Vicente, Marta;Munoz-Canoves, Pura
通讯作者：
Munoz-Canoves, Pura