Association between serum CA 19-9 and metabolic syndrome: A cross-sectional study
Association between serum CA 19-9 and metabolic syndrome: A cross-sectional study
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血清 CA 19-9 与代谢综合征之间的关联：横断面研究
DOI：
10.1111/1753-0407.12523
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发表时间：
2017-11-01
影响因子：
4.5
通讯作者：
Ning, Guang
中科院分区：
文献类型：
--
作者：
Du, Rui;Cheng, Di;Ning, Guang
背景越来越多的证据表明血清 CA 19-9 与葡萄糖代谢异常有关。然而，有关 CA 19-9 与代谢综合征之间关联的数据有限。本研究的目的是探讨血清CA 19-9与代谢综合征之间的关系。方法对中国上海市宝山区松南社区3641名40岁的参与者进行横断面研究。采用Logistic回归分析评估血清CA 19-9与代谢综合征之间的关联。结果多变量Logistic回归分析显示，与血清CA 19-9第一个三分位数的参与者相比，第二和第三个三分位数的参与者普遍代谢综合征的比值比（OR）增加（多变量调整OR 1.46 [95%置信区间{CI} 1.11-1.92]和1.51 [95% CI 1.14-1.98]；P-趋势=0.005)。此外，与血清 CA 19-9 < 37U/mL 的参与者相比，血清 CA 19-9 (37U/mL) 升高的参与者患流行性代谢综合征的风险增加（多变量调整 OR 2.10；95% CI 1.21-3.65）。结论血清 CA 19-9 与流行性代谢综合征的风险增加相关。为了证实这种关联并确定潜在的机制，应进行前瞻性队列和机制研究。
BackgroundIncreasing evidence suggests that serum CA 19-9 is associated with abnormal glucose metabolism. However, data on the association between CA 19-9 and metabolic syndrome is limited. The aim of the present study was to investigate the association between serum CA 19-9 and metabolic syndrome.MethodsA cross-sectional study was conducted on 3641 participants aged 40years from the Songnan Community, Baoshan District in Shanghai, China. Logistic regression analysis was used to evaluate the association between serum CA 19-9 and metabolic syndrome.ResultsMultivariate logistic regression analysis showed that compared with participants in the first tertile of serum CA 19-9, those in the second and third tertiles had increased odds ratios (OR) for prevalent metabolic syndrome (multivariate adjusted OR 1.46 [95% confidence interval {CI} 1.11-1.92] and 1.51 [95% CI 1.14-1.98]; P-trend=0.005). In addition, participants with elevated serum CA 19-9 (37U/mL) had an increased risk of prevalent metabolic syndrome compared with those with serum CA 19-9< 37U/mL (multivariate adjusted OR 2.10; 95% CI 1.21-3.65).ConclusionSerum CA 19-9 is associated with an increased risk of prevalent metabolic syndrome. In order to confirm this association and identify potential mechanisms, prospective cohort and mechanic studies should be performed.