PENTACHLOROPHENOL MEASUREMENTS IN BODY-FLUIDS OF PEOPLE IN LOG HOMES AND WORKPLACES
PENTACHLOROPHENOL MEASUREMENTS IN BODY-FLUIDS OF PEOPLE IN LOG HOMES AND WORKPLACES
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DOI：
10.1007/bf01055012
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发表时间：
1989-07-01
影响因子：
4
通讯作者：
NEEDHAM, LL
中科院分区：
文献类型：
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作者：
CLINE, RE;HILL, RH;NEEDHAM, LL
在正常人群（对照）、经五氯酚处理的原木房屋居民和主要在工作场所暴露的人群中评估了人类对五氯酚（PCP）的暴露。血样和尿样经提取和乙酰化后气相色谱分析。对于34个对照组，血清PCP值在15-75 ppb之间，平均值为40 ppb。123名木屋居民，平均40 ppb。123名木屋居民的血清水平在69- 1340 ppb之间，平均为420 ppb。在这些家庭中，儿童的血清水平明显高于父母，平均是父母的1.8倍。根据工作场所的不同，工人的血清和尿液中PCP的含量差异很大，血清中PCP的含量从26到84,900 ppb不等。经肌酐值校正后的尿浓度与血清浓度相关性良好（r =0.92）。用密封剂涂覆经PCP处理的室内原木可降低居民血清PCP水平。
Human exposure to pentachlorophenol (PCP) was evaluated in the normal population (controls), residents of PCP-treated log homes, and persons exposed primarily in the workplace. Blood and urine samples were analyzed by gas chromatography after extraction and acetylation. For 34 controls, serum PCP values ranged from 15-75 ppb with a mean of 40 ppb. For 123 residents of log homes, a mean of 40 ppb. For 123 residents of log homes, serum levels ranged from 69-1,340 ppb with a mean of 420 ppb. In such homes, serum levels for children were significantly higher than those for parents, averaging 1.8 times greater. Serum and urine values for workers varied widely, depending on the workplace, with serum levels ranging from 26 to 84,900 ppb of PCP. Urinary concentrations when corrected for creatinine values correlated well (r =0.92) with serum concentrations. Coating PCP-treated logs of home interiors with a sealant reduced serum PCP levels in the residents.