Pregnancy outcomes in patients with pulmonary arterial hypertension associated with congenital heart disease
Pregnancy outcomes in patients with pulmonary arterial hypertension associated with congenital heart disease
复制标题
先天性心脏病相关肺动脉高压患者的妊娠结局
DOI：
10.1136/heartjnl-2016-310003
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发表时间：
2017-02-01
期刊：
影响因子：
5.7
通讯作者：
Nizard, Jacky
中科院分区：
文献类型：
--
作者：
Ladouceur, Magalie;Benoit, Louise;Nizard, Jacky
目的越来越多的证据表明，肺动脉高压合并先天性心脏病（PAH-CHD）孕妇的孕产妇死亡率低于现有数据。为了评估这一假设，我们收集了PAH-CHD患者的妊娠数据。方法回顾性分析1997 - 2015年在法国7家转诊中心随访的PAH-CHD女性患者。所有的怀孕都被记录下来。我们收集了孕产妇、产科和新生儿结局的数据。结果20例（26 +/- 6岁）PAH-CHD患者在此期间成功妊娠28例。完全妊娠18例（>=妊娠20周），流产8例，流产2例。6例（33%,95% CI(11.9 ~ 54.3)）患者发生严重心脏事件。相关女性的静息血氧饱和度较低(79.6 +/- 4.1% vs 89.3 +/- 3.8%, p
Objective There is growing evidence that maternal mortality in pregnant women with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is lower than that in available data. In order to evaluate this hypothesis, we collected data of pregnancies in women with PAH-CHD.Methods Women with PAH-CHD followed in seven French referral centres were retrospectively included from 1997 to 2015. All pregnancies were recorded. We collected data on maternal, obstetrical and neonatal outcomes.Results 28 pregnancies in 20 women (26 +/- 6 years old) with PAH-CHD were managed during this period. There were 18 complete pregnancies (>= 20 weeks' gestation (WG)), 8 abortions and 2 miscarriages. Six (33%, 95% CI (11.9 to 54.3)) patients experienced severe cardiac events. The concerned women had lower resting oxygen saturation (79.6 +/- 4.1% vs 89.3 +/- 3.8%, p