Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases.
Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases.
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神经退行性疾病中的内质网链接。
DOI：
10.1186/s40035-017-0092-6
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发表时间：
2017
影响因子：
12.6
通讯作者：
Zhu X
中科院分区：
文献类型：
--
作者：
Liu Y;Zhu X
内质网（ER）和线粒体是管状细胞器，具有“网状结构”的特征，有助于形成细胞器间的连接。因此，线粒体相关内质网膜（MAMs）是内质网的一个亚结构域，与线粒体紧密相连并与线粒体通信，具有多种生理功能，包括脂质合成和交换、钙信号传导、生物能量学和细胞凋亡。重要的是，新出现的证据表明MAMs的异常和功能障碍与各种神经退行性疾病有关，包括阿尔茨海默病、肌萎缩侧索硬化症和帕金森病。本文就MAMs的结构、功能及其在神经退行性疾病中的作用作一综述。
Endoplasmic reticulum (ER) and mitochondria are tubular organelles with a characteristic “network structure” that facilitates the formation of inter-organellar connections. As a result, mitochondria-associated ER membranes (MAMs), a subdomain of the ER that is tightly linked to and communicates with mitochondria, serve multiple physiological functions including lipid synthesis and exchange, calcium signaling, bioenergetics, and apoptosis. Importantly, emerging evidence suggests that the abnormality and dysfunction of MAMs have been involved in various neurodegenerative disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease. This review will focus on the architecture and function of MAMs and its involvement in the neurodegenerative diseases.