Disappearance of steroid hormone dependency during malignant transformation of ovarian clear cell cancer
Disappearance of steroid hormone dependency during malignant transformation of ovarian clear cell cancer
复制标题
DOI：
10.1097/01.pgp.0000165173.90339.a2
复制
发表时间：
2005-10-01
影响因子：
2.4
通讯作者：
Okai, Takashi
中科院分区：
文献类型：
--
作者：
Akahane, Tomoko;Sekizawa, Akihiko;Okai, Takashi
卵巢透明细胞癌（OCCA）和卵巢子宫内膜样癌（OEMC）常与子宫内膜异位症相关。本研究检测了含有子宫内膜异位症和非典型子宫内膜异位症的OCCA和OEMC标本中类固醇激素受体和癌相关基因的免疫组化表达。从子宫内膜异位症到非典型子宫内膜异位症再到癌的病理进展在22例occa中有4例，在16例OEMCs中有4例。采用石蜡切割的层状组织标本，检测雌激素受体（er）和孕激素受体（pr）的表达及表达变化与观察到的病理变化的关系。从子宫内膜异位症到非典型子宫内膜异位症再到OCCA的恶性转化过程中，ER α和PRA的表达逐渐减少。在OEMC中，ER α表达随恶性转化而增加。总之，在OCCA标本中，随着子宫内膜异位症向非典型子宫内膜异位症的进展，ER α和PRA表达减少。因此，激素依赖性的消失可能与OCCA的恶性转化有关。
Ovarian clear-cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEMC) are often associated with endometriosis. This study determined the immunohistochemical expression of steroid hormone receptors and cancer-related genes in OCCA and OEMC specimens containing endometriosis and atypical endometriosis. Pathological progression from endometriosis to atypical endometriosis to carcinoma was identified in 4 of 22 OCCAs and 4 of 16 OEMCs. Using paraffin-cut bedded tissue samples, expression and changes in expression for estrogen receptors (ERs) and progesterone receptors (PRs) were examined in relation to the observed Pathological changes. A gradual reduction in ER alpha and PRA expression was observed with malignant transformation from endometriosis to atypical endometriosis to OCCA. In OEMC, ER alpha expression increased with malignant transformation. In conclusion, reductions in ER alpha and PRA expression were observed with progression from endometriosis to atypical endometriosis in OCCA specimens. Disappearance of hormone dependency might therefore be associated with malignant trans formation to OCCA.