Differential contributions of worry, anxiety, and obsessive compulsive symptoms to ERN amplitudes in response monitoring and reinforcement learning tasks.
Differential contributions of worry, anxiety, and obsessive compulsive symptoms to ERN amplitudes in response monitoring and reinforcement learning tasks.
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担忧、焦虑和强迫症状对反应监测和强化学习任务中 ERN 振幅的不同贡献。
DOI：
10.1016/j.neuropsychologia.2014.06.023
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发表时间：
2014
期刊：
影响因子：
2.6
通讯作者：
Allen,JohnJB
中科院分区：
文献类型：
--
作者：
Zambrano-Vazquez,Laura;Allen,JohnJB
强迫症（OCD）的特征是侵入性思维（即强迫）和未来导向的令人担忧的认知，这些认知与行为仪式补偿（即强迫）和焦虑唤醒有关。研究发现，强迫症患者在选择反应任务（如侧翼任务）中的错误相关负性（ERN）增强，但在概率学习任务中则没有。到目前为止，研究还没有直接调查在强迫症患者中观察到的ERN效应是否与强迫症（强迫症和强迫症）的中心特征有关，或者与这种疾病中观察到的担忧或焦虑更密切相关。本研究比较了具有相对纯的OC、担心和焦虑症状（例如，OC高，担心和焦虑低）的症状特征的组相对于“典型”OC呈现组（例如，高OC，轻度到高度担心和焦虑）和非焦虑非担心对照组，在侧翼和概率学习任务中。对于侧翼任务，只有担心组相对于对照组有显著增强的ERN。对于概率学习任务，OC典型组相对于对照组在次优选择上显著增强了ERN振幅。在所有任务中，实验组相对于OC特定组在错误/次优选择上的活动显著增强。结果突出了在这两项任务中，焦虑和OC症状在性能监控过程中的作用。
Obsessive–Compulsive Disorder (OCD) is characterized by intrusive thoughts (i.e. obsessions) and future-oriented worrisome cognitions that are associated with behavioral ritualistic compensations (i.e. compulsions) and anxious arousal. Research has found an enhanced error-related negativity (ERN) among those with OCD in choice response tasks such as the flankers task, but not in probabilistic learning tasks. To date, research has not directly investigated whether the ERN effect observed in individuals with OCD is specific to the central features of OCD (obsessions and compulsions), or is related more closely to the worry or anxiety observed in this disorder. This study compared groups with relatively pure symptom profiles on OC, worry, and anxiety symptoms (e.g. high on OC, low on worry and anxiety) relative to a “typical” OC presentation group (e.g. high OC, mild to high worry and anxiety) and a non-anxious non-worry Control group, in both flankers and probabilistic learning tasks. For the flankers task, only the Worry group had a significantly enhanced ERN relative to controls. For the probabilistic learning task, the OC typical group had significantly enhanced ERN amplitude on suboptimal choices relative to controls. Across tasks, the experimental groups had significantly enhanced activity on error/suboptimal choices relative to the OC specific group. The results highlight the role of worry across both tasks, and to a lesser extent anxiety and OC symptoms, in performance-monitoring processes.