Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity.
Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity.
复制标题
反义转录启动子的特征及其活性调节。
DOI：
10.3390/ijms17010009
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发表时间：
2015-12-23
影响因子：
5.6
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Lin S;Zhang L;Luo W;Zhang X
近年来，对天然反义转录物的分类、时空表达模式、调控功能和机制等方面的研究越来越多。自然的反义转录本是由与编码蛋白质的链相反的链产生的。尽管天然反义转录物在调控靶基因表达中起着关键作用，但反义启动子（asp）启动的转录机制尚不清楚。迄今为止，几乎所有关于这一主题的研究都集中在单个感兴趣基因的ASP上，而没有研究系统地分析ASP在基因组中的位置、ASP活性或影响其活性的因素。本文将重点阐述和总结asp的特点，以扩展我们对反义转录物起始机制的认识。
Recently, an increasing number of studies on natural antisense transcripts have been reported, especially regarding their classification, temporal and spatial expression patterns, regulatory functions and mechanisms. It is well established that natural antisense transcripts are produced from the strand opposite to the strand encoding a protein. Despite the pivotal roles of natural antisense transcripts in regulating the expression of target genes, the transcriptional mechanisms initiated by antisense promoters (ASPs) remain unknown. To date, nearly all of the studies conducted on this topic have focused on the ASP of a single gene of interest, whereas no study has systematically analyzed the locations of ASPs in the genome, ASP activity, or factors influencing this activity. This review focuses on elaborating on and summarizing the characteristics of ASPs to extend our knowledge about the mechanisms of antisense transcript initiation.