NICOTINE - A DIFFERENT APPROACH TO TREATMENT OF OBSTRUCTIVE SLEEP-APNEA
NICOTINE - A DIFFERENT APPROACH TO TREATMENT OF OBSTRUCTIVE SLEEP-APNEA
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DOI：
10.1378/chest.87.1.11
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发表时间：
1985-01-01
期刊：
影响因子：
9.6
通讯作者：
CHERNIACK, NS
中科院分区：
文献类型：
--
作者：
GOTHE, B;STROHL, KP;CHERNIACK, NS
上呼吸道肌肉活动减少可能是睡眠期间发生阻塞性呼吸暂停的原因之一。这些呼吸暂停的治疗没有统一的成功方法，增加上呼吸道肌肉活动的药物可能会减少睡眠期间阻塞的发生。尼古丁是一种已知的呼吸刺激剂，它还会增加肌肉的活动，使上呼吸道的扩张比例超过通气量。观察了8例睡眠呼吸暂停综合征患者入睡后2 h内尼古丁对呼吸暂停的影响。尼古丁可减少睡眠早期的呼吸暂停，这种效果可能是由于尼古丁对上呼吸道肌肉的刺激作用造成的。
Reduced upper airway muscle activity may contribute to the occurrence of obstructive apneas during sleep. There is no uniformly successful treatment of these apneas, and it is possible that agents which increase upper airway muscle activity could reduce the occurrence of obstruction during sleep. Nicotine, a known stimulant of breathing, also increases the activity of muscles which dilate the upper airway proportionally more than it does ventilation. The effect of nicotine was evaluated on apneas during the first 2 h of sleep in 8 patients with sleep apnea syndrome. Nicotine reduces apneas during the early hours of sleep, and this effect may be caused by its stimulating action on upper airway muscles.