EXTRAMACROCHAETAE, A NEGATIVE REGULATOR OF SENSORY ORGAN DEVELOPMENT IN DROSOPHILA, DEFINES A NEW CLASS OF HELIX-LOOP-HELIX PROTEINS
EXTRAMACROCHAETAE, A NEGATIVE REGULATOR OF SENSORY ORGAN DEVELOPMENT IN DROSOPHILA, DEFINES A NEW CLASS OF HELIX-LOOP-HELIX PROTEINS
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DOI：
10.1016/0092-8674(90)90212-w
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发表时间：
1990-04-06
期刊：
影响因子：
64.5
通讯作者：
POSAKONY, JW
中科院分区：
文献类型：
--
作者：
ELLIS, HM;SPANN, DR;POSAKONY, JW
果蝇成体感觉器官的正常空间模式需要大毛外毛(EMC)基因的功能。EMC抑制体表某些区域的感觉器官发育，显然是通过对抗无毛虫和刺毛虫基因的功能(AS-C)。我们发现EMC编码了螺旋-环-螺旋(HLH)家族的一个新成员。EMC蛋白具有其他HLH蛋白的二聚化结构域，但缺乏它们的DNA结合基序。我们提出了一个模型，在这个模型中，EMC蛋白通过与AS-C和/或无子女编码的HLH蛋白形成异源二聚体，从而改变或干扰它们的活性，从而负向调节感觉器官的决定。
The function of the extramacrochaetae (emc) gene is required to establish the normal spatial pattern of adult sensory organs in Drosophila. emc acts to suppress sensory organ development in certain regions of the body surface, apparently by antagonizing the function of the achaete and scute genes of the achaetescute complex (AS-C). We have found that emc encodes a novel member of the helix-loop-helix (HLH) family of proteins. The emc protein shares the dimerization domain of other HLH proteins but lacks their DNA binding motif. We propose a model in which the emc protein negatively regulates sensory organ determination by forming heterodimers with the HLH proteins encoded by the AS-C and/or daughterless, thereby altering or interfering with their activity.