Increased circulating T-helper 22 cells in patients with dilated cardiomyopathy
Increased circulating T-helper 22 cells in patients with dilated cardiomyopathy
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DOI：
10.3892/mmr.2014.2146
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发表时间：
2014-07-01
影响因子：
3.4
通讯作者：
Xue, Yimin
中科院分区：
文献类型：
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作者：
Kong, Qing;Li, Xiaomo;Xue, Yimin
最近，新确定的产生白细胞介素（IL）-22的辅助性T细胞（Th）22细胞已被牵连参与自身免疫性疾病的发病机制。然而，其在扩张型心肌病（DCM）发病机制中的作用尚未阐明。共30例DCM患者和30例健康对照者入组本研究。采用流式细胞仪检测外周血Th 22、Th 17和Th 1细胞水平。采用ELISA法检测血浆IL-22和自身抗体ANT水平。Th 22的关键转录因子，芳烃受体（AHR），采用定量聚合酶链反应进行了评估。另外，还收集了脑钠肽（BNP）、C反应蛋白（CRP）和红细胞沉降率（ESR）的临床资料。与对照组相比，DCM患者Th 22、Th 17和Th 1细胞水平均显著升高（P
Recently, the newly determined interleukin (IL)-22-producing T-helper (Th) 22 cell has been implicated to be involved in the pathogenesis of autoimmune diseases. However, its role in the pathogenesis of dilated cardiomyopathy (DCM) has yet to be elucidated. A total of 30 patients with DCM and 30 healthy controls were enrolled in the present study. The levels of Th22, Th17 and Th1 cells in the peripheral blood were analyzed by flow cytometry. Levels of plasma IL-22 and autoantibody adenine nucleotide translocator (ANT) were assessed using the ELISA. The key transcription factor of Th22, aryl hydrocarbon receptor (AHR), was assessed using quantitative polymerase chain reaction. Additionally, clinical data on the brain natriuretic peptide (BNP), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were collected. In comparison with those in the control group, significantly elevated levels of Th22, Th17 and Th1 cells were detected in patients with DCM (all P