Thermo responsive DNA/polymer conjugate for intelligent antisense strategy
Thermo responsive DNA/polymer conjugate for intelligent antisense strategy
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DOI：
10.1246/cl.2003.266
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发表时间：
2003-03-05
影响因子：
1.6
通讯作者：
Maeda, M
中科院分区：
文献类型：
--
作者：
Murata, M;Kaku, W;Maeda, M
制备了20聚体反义寡核苷酸(ODN)与温度响应性聚合物聚N-异丙基丙烯酰胺(PNIPAAm)的偶联物。偶联物与其靶RNA之间的杂交反应受温度条件下聚合物部分构象变化的调节。
The conjugate between 20-mer antisense oligodeoxynucleotides (ODN) and thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), was prepared. Hybridization reaction between the conjugate and their target RNA was modulated by conformational change of polymer moiety depending on temperature condition.