Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex
Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex
复制标题
DOI：
10.1021/ja053946n
复制
发表时间：
2005-10-12
影响因子：
15
通讯作者：
Shibasaki, M
中科院分区：
文献类型：
--
作者：
Takita, R;Yakura, K;Shibasaki, M
描述了使用催化量的In（III）/BINOL的芳香族和脂肪族醛的不对称炔基化。由于铟（III）催化剂的“双功能特性”，两种底物的双重活化使得能够实现具有高对映体选择性（83至> 99%ee）的宽范围的底物通用性。
Asymmetric alkynylation of both aromatic and aliphatic aldehydes using catalytic amounts of In(III)/BINOL is described. Dual activation of both substrates due to the “bifunctional character” of the indium(III) catalyst enables a broad range of substrate generality with high enantioselectivity (83 to >99% ee).