SecA-a New Twist in the Tale.
SecA-a New Twist in the Tale.
复制标题
DOI：
10.1128/jb.00736-16
复制
发表时间：
2017-01-15
影响因子：
3.2
通讯作者：
Collinson I
中科院分区：
文献类型：
--
作者：
Collinson I
发表在本期《细菌学杂志》上的一篇论文（D。Huber，M.贾姆沙德河Hanmer，D. Schibich，K.德林岛Marcomini，G.克雷默和B。Bukau，J Bacteriol 199：e0622-16，2017，https：//doi.org/10.1128/JB.00622-16）及时提醒我们，在一般细菌分泌系统中，一切都不像我们以前想象的那么清楚。本文描述了一种新的分泌模式，通过Sec系统-“非偶联共易位”-蛋白质穿过细菌内膜，并建议我们重新考虑的性质和机制的目标和运输步骤对蛋白质出口。
A paper published in this issue of the Journal of Bacteriology (D. Huber, M. Jamshad, R. Hanmer, D. Schibich, K. Döring, I. Marcomini, G. Kramer, and B. Bukau, J Bacteriol 199:e0622-16, 2017, https://doi.org/10.1128/JB.00622-16) provides us with a timely reminder that all is not as clear as we had previously thought in the general bacterial secretion system. The paper describes a new mode of secretion through the Sec system—“uncoupled cotranslocation”—for the passage of proteins across the bacterial inner membrane and suggests that we might rethink the nature and mechanism of the targeting and transport steps toward protein export.