Taurine and Chinese traditional medicine accelerate alcohol metabolism in mice.
Taurine and Chinese traditional medicine accelerate alcohol metabolism in mice.
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DOI：
10.1007/978-1-4614-6093-0_3
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发表时间：
2013
影响因子：
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通讯作者：
Gaofeng Wu;Jiancheng Yang;Shumei Lin;Ying Feng;Qunhui Yang;Qiufeng Lv;Jianmin Hu
中科院分区：
文献类型：
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作者：
Gaofeng Wu;Jiancheng Yang;Shumei Lin;Ying Feng;Qunhui Yang;Qiufeng Lv;Jianmin Hu
过量饮酒是危险的，会对健康造成严重损害。酒精氧化的主要器官是肝脏，也是合成牛磺酸的主要器官，牛磺酸是一种含硫β-氨基酸，是细胞内主要的游离氨基酸，存在于人和动物的许多组织中，发挥多种生理和药理功能。为了探讨牛磺酸和中药对急性饮酒后酒精代谢的影响，给雄性昆明小鼠灌胃60%酒精（0.4 ml）。小鼠在饮酒前或饮酒后30分钟灌胃水、牛磺酸或牛磺酸与中药合用。以小鼠翻正反射的消失来判断是否中毒。记录酒精摄入和中毒之间的持续时间（耐受时间）、中毒和恢复之间的持续时间（维持时间）。饮酒后20、50、90、120、150 min检测血液酒精浓度、肝乙醇脱氢酶（ADH）、乙醛脱氢酶（ALDH）水平。结果表明，牛磺酸单独给药或与中药合用均能显着减少小鼠中毒数量，推迟耐受时间，缩短维持时间，并能明显降低血液中酒精含量，升高肝脏ADH和ALDH水平。结果表明，牛磺酸单用或与中药合用均能显着加速酒精代谢，降低酒精毒性，且牛磺酸与中药合用效果更佳。
Excessive alcohol consumption is dangerous and causes serious damage to health. The main organ capable of alcohol oxidizing is liver which is also the main organ synthesizing taurine, a sulfur-containing β-amino acid, which is the major free intracellular amino acid presenting in many tissues of human and animals and exerting many physiologic and pharmacologic functions. To investigate the effect of taurine and Chinese traditional medicine on alcohol metabolism after acute alcoholic intake, male Kunming mice were administered with 60% alcohol (0.4 ml) intragastrically. Water, taurine, or taurine coadministration with Chinese traditional medicine was intragastrically administered to mice 30 min before or after alcohol intake. The disappearance of body-righting reflex was used to determine the intoxication of mice. Durations between alcohol intake and intoxication (tolerance time), intoxication and recovery (maintenance time) were recorded. The concentration of blood alcohol, levels of hepatic alcohol dehydrogenase (ADH), and acetaldehyde dehydrogenase (ALDH) were detected at 20, 50, 90, 120, and 150 min after alcohol intake. The results showed that taurine administered alone or together with Chinese traditional medicine could both significantly reduce the number of intoxicated mice, postpone the tolerance time, shorten the maintenance time, and could obvisouly decrease blood level of alcohol, increase hepatic levels of ADH and ALDH. The results indicated that taurine administered alone or together with traditional Chinese medicine could significantly accelerate the metabolism of alcohol, reduce the toxicity of alcohol, and coadministration of taurine and traditional Chinese medicine had better effects.