The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense.

The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense.
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DOI:
10.1016/j.molcel.2023.07.013
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发表时间:
2023-08
期刊:
影响因子:
16
通讯作者:
Boyi Gan
Boyi Gan
中科院分区:
生物学1区
文献类型:
--
作者:
Boyi Gan

文献摘要

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Yang等人最近的一项研究揭示了嘧啶体,这是一种多酶复合物,来自不同亚细胞区室的酶协同实现有效的嘧啶生物合成和铁中毒防御,突出了细胞代谢的显著适应性和新的治疗机会。
A recent study by Yang et al.1uncovers the pyrimidinosome, a multienzyme complex where enzymes from different subcellular compartments collaborate to enable efficient pyrimidine biosynthesis and ferroptosis defense, highlighting the remarkable adaptability of cellular metabolism and new therapeutic opportunities.