IL-2 induces a competitive survival advantage in T lymphocytes
IL-2 induces a competitive survival advantage in T lymphocytes
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DOI：
10.4049/jimmunol.172.10.5973
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发表时间：
2004-05-15
影响因子：
4.4
通讯作者：
Abbas, AK
中科院分区：
文献类型：
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作者：
Dooms, H;Kahn, E;Abbas, AK
激活的T淋巴细胞获得长期生存潜力对于确保在淋巴系统的竞争环境中成功发展记忆群体是至关重要的。赋予致敏T细胞生存竞争力的因素定义不清。我们研究了IL-2信号在诱导CD 4（+）T细胞长期存活过程中的作用。我们发现，Ag诱导的CD 4（+）IL-2（-/-）T细胞的周期是独立的IL-2在体外。然而，IL-2（-/-）T细胞未能大量积累，并在效应细胞中发展时，在没有IL-2的情况下引发。更重要的是，Ag激活的IL-2（-/-）T细胞在未经操作的同基因小鼠中过继转移后不能存活很长时间。然而，在致敏期间暴露于IL-2信号的IL-2（-/-）T细胞获得了比在不存在IL-2的情况下循环的细胞更稳健和持久的存活优势。有趣的是，这种IL-2诱导的存活程序是在完整的淋巴区室中致敏的IL-2（-/-）T细胞长期持续存在所必需的，但在淋巴细胞减少的环境中是不必要的。因此，IL-2增强了CD 4（+）T细胞的生存竞争力，从而促进了记忆群体的发育。
The acquisition of long-term survival potential by activated T lymphocytes is essential to ensure the successful development of a memory population in the competitive environment of the lymphoid system. The factors that grant competitiveness for survival to primed T cells are poorly defined. We examined the role of IL-2 signals during priming of CD4(+) T cells in the induction of a long-lasting survival program. We show that Ag-induced cycling of CD4(+) IL-2(-/-) T cells is independent of IL-2 in vitro. However, IL-2(-/-) T cells failed to accumulate in large numbers and develop in effector cells when primed in the absence of IL-2. More importantly, Ag-activated IL-2(-/-) T cells were unable to survive for prolonged periods of time after adoptive transfer in unmanipulated, syngeneic mice. IL-2(-/-) T cells exposed to IL-2 signals during priming, however, acquired a robust and long-lasting survival advantage over cells that cycled in the absence of IL-2. Interestingly, this IL-2-induced survival program was required for long-term persistence of primed IL-2(-/-) T cells in an intact lymphoid compartment, but was unnecessary in a lymphopenic environment. Therefore, IL-2 enhances competitiveness for survival in CD4(+) T cells, thereby facilitating the development of a memory population.