Rhythm of digestion: keeping time in the gastrointestinal tract
Rhythm of digestion: keeping time in the gastrointestinal tract
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DOI：
10.1111/j.1440-1681.2009.05254.x
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发表时间：
2009-10-01
影响因子：
2.9
通讯作者：
Furness, John B.
中科院分区：
文献类型：
--
作者：
Bron, Romke;Furness, John B.
P>1。最典型的哺乳动物昼夜节律遵循视交叉上核中的光夹带中央主起搏器，并与时钟基因的活动波动相关，包括 Clock、Bmal1、Per 和 Cry，其产物与效应基因启动子中的序列结合。这是中央时钟。2。在本综述中，我们讨论了一种独立但相互作用的、与肠道相关的生物钟，即外周时钟，它是由食物引起的。3。昼夜节律的破坏与多种病理有关，最显着的是与新陈代谢有关，但昼夜节律的破坏对消化系统的影响研究较少，尽管也可能导致功能性后果。有线索表明，与炎症、癌症和运动相关的胃肠道疾病与外周节律紊乱之间存在联系。旨在了解这些联系的研究仍处于起步阶段。4．我们还为研究人员讨论了胃肠组织中存在昼夜节律的实际问题，涉及实验设计、数据解释和动物模型的选择。5。目前有足够的证据表明昼夜节律对肠道功能、新陈代谢和粘膜防御很重要，进一步的研究将揭示节律紊乱和胃肠道功能障碍之间的联系。
P>1. The best characterized mammalian circadian rhythms follow a light-entrained central master pacemaker in the suprachiasmatic nucleus and are associated with fluctuations in the activities of clock genes, including Clock, Bmal1, Per and Cry, the products of which bind to sequences in the promoters of effector genes. This is the central clock.2. In the present review, we discuss evidence for an independent, but interacting, gut-associated circadian clock, the peripheral clock, which is entrained by food.3. Disruption of circadian rhythms is associated with a wide range of pathologies, most prominently metabolism linked, but the effects of disruption of circadian rhythms on the digestive system are less well studied, although also likely to lead to functional consequences. There are clues suggestive of links between gastrointestinal disorders related to inflammation, cancer and motility and disruption of peripheral rhythms. Research aimed at understanding these links is still in its infancy.4. We also discuss practical aspects of the presence of circadian rhythms in gastrointestinal tissues for researchers related to experimental design, data interpretation and the choice of animal models.5. There is currently sufficient evidence to suggest that circadian rhythms are important to gut function, metabolism and mucosal defence and that further investigation will uncover connections between disordered rhythms and gastrointestinal malfunction.