Do Cellular Condensates Accelerate Biochemical Reactions? Lessons from Microdroplet Chemistry.
Do Cellular Condensates Accelerate Biochemical Reactions? Lessons from Microdroplet Chemistry.
复制标题
细胞凝聚物会加速生化反应吗？
DOI：
10.1016/j.bpj.2018.05.023
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发表时间：
2018
影响因子：
3.4
通讯作者：
Schnell,Santiago
中科院分区：
文献类型：
--
作者：
Stroberg,Wylie;Schnell,Santiago
细胞凝聚物--蛋白质和核酸的相分离的浓缩物--为生物化学提供了有别于膜结合室的组织结构。有人提出，细胞凝聚物的一个主要功能是加速通常缓慢的或热力学上不利的生化过程。然而，导致细胞凝聚物中反应速率增加的机制仍然知之甚少。在这篇文章中，我们重点介绍了微滴化学方面的最新进展，这些微滴化学将反应速度提高了许多个数量级，并暗示类似的机制也可能影响细胞凝聚物中的反应动力学。
Cellular condensates—phase-separated concentrates of proteins and nucleic acids—provide organizational structure for biochemistry that is distinct from membrane-bound compartments. It has been suggested that one major function of cellular condensates is to accelerate biochemical processes that are normally slow or thermodynamically unfavorable. Yet, the mechanisms leading to increased reaction rates within cellular condensates remain poorly understood. In this article, we highlight recent advances in microdroplet chemistry that accelerate reaction rates by many orders of magnitude as compared to bulk and suggest that similar mechanisms may also affect reaction kinetics in cellular condensates.