KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 (Retracted article. See vol. 52, 2023)
KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 (Retracted article. See vol. 52, 2023)
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DOI：
10.3892/ijmm.2021.4932
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发表时间：
2021-06-01
影响因子：
5.4
通讯作者：
Han, Qingjiang
中科院分区：
文献类型：
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作者：
Zheng, Pengyi;Wu, Kaijie;Han, Qingjiang
膀胱癌（Bladder cancer，BC）是泌尿系统最常见的恶性肿瘤之一，发病率和死亡率都很高。尽管在膀胱癌的诊断和治疗方面取得了进展，但靶向治疗仍然是最有希望的治疗方法，迫切需要新的治疗靶点来改善BC患者的结局。驱动蛋白家族成员4A（Kinesin family member 4A，KIF4A）是一种正末端定向运动蛋白，参与多种细胞过程的调控，如有丝分裂和轴突生长。值得注意的是，KIF4A在肿瘤生长和进展中起重要作用，其表达与几种类型癌症的预后相关。然而，KIF4A在膀胱癌发展中的潜在作用和分子机制仍不清楚。目前的研究表明，KIF4A在人类BC组织中高表达，其表达与患者的临床病理特征，如肿瘤分期（P=0.012）和与BC患者的预后有关。进一步发现KIF4A在体外和体内均促进膀胱癌细胞增殖。总的来说，本文提供的数据提供了KIF4A通过CDCA 3表达的转录激活促进BC发展的证据。本研究表明KIF4A参与了BC的进展，并表明KIF4A可能是治疗BC的有希望的治疗靶点。
Bladder cancer (BC) is among the most common urinary system tumors with a high morbidity and mortality worldwide. Despite advancements being made in the diagnosis and treatment of bladder cancer, targeted therapy remains the most promising treatment, and novel therapeutic targets are urgently required in to improve the outcomes of patients with BC. Kinesin family member 4A (KIF4A) is a plus-end directed motor protein involved in the regulation of multiple cellular processes, such as mitosis and axon growth. Notably, KIF4A plays important roles in tumor growth and progression, and its expression is associated with the prognosis of several types of cancer. However, the potential role and molecular mechanisms of KIF4A in bladder cancer development remain unclear. The present study demonstrated that KIF4A was highly expressed in human BC tissues, and its expression was associated with patient clinicopathological characteristics, such as tumor stage (P=0.012) and with the prognosis of patients with BC. It was further found that KIF4A promoted the cell proliferation of bladder cancer both in vitro and in vivo. On the whole, the data presented herein provide evidence that KIF4A promotes the development of BC through the transcriptional activation of the expression of CDCA3. The present study indicates the involvement of KIF4A in the progression of BC and suggests that KIF4A may be a promising therapeutic target for the treatment of BC.