Lipids in Nuclei of Neocortex Neurons and Gib under CNS-Syndrome in Rats
Lipids in Nuclei of Neocortex Neurons and Gib under CNS-Syndrome in Rats
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DOI：
10.7868/s0869803114050099
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发表时间：
2014-11-01
期刊：
影响因子：
--
通讯作者：
Kolomiytseva, I. K.
中科院分区：
文献类型：
--
作者：
Markevich, L. N.;Kolomiytseva, I. K.
大鼠头部局部暴露于剂量为200戈伊的X射线辐射对新皮层神经元和神经胶质细胞核部分中磷脂和中性脂质数量的影响进行了研究。在运动障碍修复时，辐射后2小时，神经元核中磷脂酰肌醇的量减少，鞘磷脂的量增加。新皮层神经胶质细胞核中磷脂酰胆碱和磷脂酰肌醇的含量下降，鞘磷脂和胆固醇的含量增加。神经元核的鞘磷脂、磷脂酰肌醇、磷脂酰胆碱和胆固醇参与哺乳动物CNS综合征的动力学过程。已证实哺乳动物CNS综合征脂质核反应的放射抗性，并提出脂质在照射后DNA修复中的可能作用。
The effect of a local exposure of rat heads to X-ray radiation at a dose of 200 Gy on the number of phospholipids and neutral lipids in the nuclear fraction of neocortex neurons and glia has been investigated A decrease in the amount of phosphatidylinositol and an increase in sphingomyelin in neuronal nuclei occurred 2 h after irradiation at the time of repair of locomotive disorders. The amount of phosphatidylcholine and phosphatidylinositol dropped, and the amount of sphingomyelin and cholesterol increased in the nuclei of glial cells of the neocortex. Sphingomyelin, phosphatidylinositol, phosphatidylcholine and cholesterol of neuronal nuclei are involved in the dynamics of the CNS syndrome in mammals Radio resistance of the responses of lipid nuclei in mammals with the CNS syndrome has been shown and a possible role of lipids in the post-irradiation DNA repair has been suggested.