Premature ventricular contraction-induced cardiomyopathy: Related clinical and electrophysiologic parameters
Premature ventricular contraction-induced cardiomyopathy: Related clinical and electrophysiologic parameters
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DOI：
10.1016/j.hrthm.2015.08.025
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发表时间：
2016-01-01
期刊：
影响因子：
5.5
通讯作者：
Maury, Philippe
中科院分区：
文献类型：
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作者：
Blaye-Felice, Marie Sadron;Hamon, David;Maury, Philippe
与室性早搏诱发的心肌病（PVCi-CMP）相关的背景因素仍然存在争议。目的本研究的目的是在一个大型多中心population.METHODS中测试各种因素与PVCi-CMP存在的相关性。患者分为2组：第1组疑似PVCi-CMP（96例患者，射血分数38% +/- 100/0，左心室舒张末期直径62 +/- 8 mm，伴或不伴其他结构性心脏病）;第2组（对照组，72例射血分数和左心室尺寸正常的患者）。在单变量分析中，左心室起源的PVC，缺乏心悸，长PVC耦合间隔，心外膜起源的焦点，长窦性搏动QRS持续时间，男性，高PVC负担，多态性PVC的存在，高PVC QRS持续时间，和年龄较大的组之间进行了比较。在多变量分析中，只有缺乏心悸、PVC负荷和心外膜起源与心肌病的存在显著且独立相关。即使窦性QRS持续时间或PVC左心室的起源也被发现独立地与PVCi-CMP在整个人口中，他们不再相关时，患者有额外的心脏疾病excluded.CONCLUSION缺乏心悸，PVC负担，和心外膜的起源是独立的因素，确定患者容易发展PVCi-CMP。
BACKGROUND Factors associated with premature ventricular contraction-induced cardiomyopathy (PVCi-CMP) remain debated.OBJECTIVE The purpose of this study was to test the correlation of various factors to the presence PVCi-CMP in a large multicenter population.METHODS One hundred sixty-eight consecutive patients referred for ablation of frequent premature ventricular contractions (PVCs) were included. Patients were divided into 2 groups: group 1 with suspected PVCi-CMP (96 patients, ejection fraction 38% +/- 100/0, left ventricular end-diastolic diameter 62 +/- 8 mm, with or without additional structural heart disease); and group 2 (control group, 72 patients with normal ejection fraction and left ventricular dimensions). Various clinical and electrophysiologic parameters were compared between groups.RESULTS In univariate analysis, left ventricular origin of PVC, lack of palpitations, long PVC coupling interval, epicardial origin of the focus, long sinus beat QRS duration, male gender, high PVC burden, presence of polymorphic PVCs, high PVC QRS duration, and older age were significantly related to the presence of PVCi-CMP. In multivariate analysis, only lack of palpitations, PVC burden, and epicardial origin remained significantly and independently correlated with the presence of cardiomyopathy. Even if sinus QRS duration or PVC left ventricular origin were also found independently linked to PVCi-CMP in the whole population, they were no longer correlated when patients with additional heart disease were excluded.CONCLUSION Lack of palpitations, PVC burden, and epicardial origin are independent factors that identify patients prone to developing PVCi-CM P.