Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans.
Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans.
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DOI：
10.1161/hypertensionaha.109.148619
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Fisher ND
中科院分区：
文献类型：
--
作者：
Forman JP;Williams JS;Fisher ND
Vitamin D regulates the renin angiotensin system in experimental animals, but corresponding human data are limited. We examined the relation between plasma 25-hydroxyvitamin D and elements of the renin angiotensin system in 184 normotensive individuals in high sodium balance; these included circulating levels of plasma renin activity and angiotensin II, and the renal plasma flow response to infused angiotensin II, which is an indirect measure of the intrinsic renin angiotensin system activity in the kidney. Compared to individuals with sufficient 25-hydroxyvitamin D levels (≥ 30 ng/mL), those with insufficiency (15 - 29.9 ng/mL) and deficiency (<15 ng/mL) had higher circulating angiotensin II levels (p-trend = 0.03). Moreover, those with vitamin D deficiency had significantly blunted renal plasma flow responses to infused angiotensin II (mean decrease of 115 mL/min/1.732 in renal plasma flow vs. 145 ml/min/1.73m2 among those with sufficient vitamin D levels; p-trend = 0.009). Although plasma renin activity was higher among individuals with insufficient levels of vitamin D, the result was not statistically significant. These data suggest that low plasma 25-hydroxyvitamin D levels may result in upregulation of the renin angiotensin system in otherwise healthy humans.
