eIF5B increases ASAP1 expression to promote HCC proliferation and invasion.
eIF5B increases ASAP1 expression to promote HCC proliferation and invasion.
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eIF5B 增加 ASAP1 表达，促进 HCC 增殖和侵袭。
DOI：
10.18632/oncotarget.11469
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发表时间：
2016-09-20
期刊：
影响因子：
--
通讯作者：
Zhou WP
中科院分区：
文献类型：
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作者：
Wang ZG;Zheng H;Gao W;Han J;Cao JZ;Yang Y;Li S;Gao R;Liu H;Pan ZY;Fu SY;Gu FM;Xing H;Ni JS;Yan HL;Ren H;Zhou WP
肝细胞癌（HCC）是世界范围内第三大常见的癌症相关死亡原因。尽管在过去的十年中已经取得了治疗进展，但HCC的分子发病机制仍然知之甚少。在这项研究中，我们发现真核生物翻译起始因子5B（eIF5B）的表达增加与侵袭性特征显著相关，并与大型队列中较短的无复发生存期（RFS）和总生存期（OS）相关。我们还发现eIF5B在体外和体内促进HCC细胞增殖和迁移，部分是通过增加ASAP 1的表达。我们的研究结果强烈表明eIF5B可以促进HCC进展，并被认为是HCC的预后生物标志物。
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. Despite the therapeutic advances that have been achieved during the past decade, the molecular pathogenesis underlying HCC remains poorly understood. In this study, we discovered that increased expression eukaryotic translation initiation factor 5B (eIF5B) was significantly correlated with aggressive characteristics and associated with shorter recurrence-free survival (RFS) and overall survival (OS) in a large cohort. We also found that eIF5B promoted HCC cell proliferation and migration in vitro and in vivo partly through increasing ASAP1 expression. Our findings strongly suggested that eIF5B could promote HCC progression and be considered a prognostic biomarker for HCC.