Effects of selective toxic lesions of cholinergic neurons of the laterodorsal tegmental nucleus on experimental seizures.
Effects of selective toxic lesions of cholinergic neurons of the laterodorsal tegmental nucleus on experimental seizures.
复制标题
外侧被盖核胆碱能神经元选择性毒性损伤对实验性癫痫发作的影响。
DOI：
10.1016/0006-8993(92)90756-y
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发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Bardgett,ME
中科院分区：
文献类型：
--
作者：
Miller,JW;Gray,BC;Bardgett,ME
本研究确定了双侧离散部分毁损桥中脑被盖背外侧核（LDTg）胆碱能神经元对戊四氮（PTZ）诱导癫痫发作的影响。相对选择性病变产生的双边50 nl微量注射75 pmol的胆碱能神经毒素乙基胆碱氮芥aziridinium离子（AF64A）导致肌阵挛和面部前肢阵挛性癫痫发作的阈值显着降低，但不是强直性癫痫发作时，PTZ输注7天后。这表明胆碱能核是皮层下癫痫发作调控的关键部位。我们建议，这种控制是介导的上升预测从LDTg中央内侧板内核的丘脑。
This study determined the effects of bilateral discrete partial lesions of cholinergic neurons of the laterodorsal tegmental nucleus (LDTg) of the pontomesencephalic tegmentum on seizures induced by intravenous pentylenetetrazol (PTZ). Relatively selective lesions produced by bilateral 50 nl microinjections of 75 pmol of the cholinergic neurotoxin ethylcholine mustard aziridinium ion (AF64A) resulted in a significant reduction in the threshold of myoclonic and facial-forelimb clonic seizures but not tonic seizures when PTZ was infused 7 days later. This demonstrates that this cholinergic nucleus is a key site of subcortical seizure regulation. We propose that this control is mediated by ascending projections from the LDTg to the central medial intralaminar nucleus of the thalamus.